As these mice are more genetically heterogeneous, there may be greater mouse-to-mouse phenotypic variability than inbred mice. By avoiding these crosses, this strain can retain greater genetic diversity and improve animal vigor. This strain is maintained using a highly specialized outbred mating scheme, which avoids mating between closely related individuals. As noted in the datastrain sheet, these NU/J inbred mice have a homogenous mouse genetic background, which allows for highly consistent and reproducible growth of many allogeneic cell lines. Here’s some information on the strains most often used by researchers:īy definition, an inbred strain is produced using matings between brother and sister or parent and offspring, for at least 20 generations. Today, JAX now maintains several nude strains from NIH. In 1975, The Jackson Laboratory (JAX) imported the Foxn1nu mutation from the National Institutes of Health (NIH) on an outbred stock of mice. What nude mouse strains exist, and how do they differ? Taken together, these characteristics of the nude mice make them an excellent model for xenografting tumor cell lines, understanding mechanisms of tumor malignancy, and testing the impact of potential treatments (Price, 2001). These phenotypes are useful as it allows a range of foreign cells or tissue to engraft into the mouse host. This also results in a lack of antibody production (Muqbil, Philip, & Mohammad, 2019 Wettersten et al., 2014). Thus, nude mice lack a proper thymus, T cell maturation, and may show small amounts of sparse, generally abnormal fur or whiskers that are structurally weak and break as they grow (Mecklenburg et al., 2004).īeing athymic, they do not produce mature T cells and exhibit a reduced number of circulating lymphocytes, as compared to wildtype or heterozygous controls. Due to their immuno-comprised phenotype, they have proven to be useful for xenografts, particularly in cancer research (Wettersten, Ganti, & Weiss, 2014 Szadvar, I et al., 2016). Nude mice are an invaluable tool in biomedical research and drug discovery. So if you have a colleague who’s using nude mice, or you are starting to use them yourself, here is some background information on these models and some tips on handling them. But even through the years, nude mice remain just as relevant today as they were then in a variety of therapeutic areas, including oncology and immunology. In the 50-plus years since the discovery of nude mice, the field has changed significantly due to the development of gene-targeting technology. ![]() This is a particular mouse strain that has a mostly “hairless” phenotype (Pantelouris 1968 Mecklenburg L et al., 2004). It was in the 1960s that the first publication specifically mentioned nude mice, also known as athymic mice. Their relatively small size, and both genetic and physiological similarity to humans, make mice a model organism for human disease. Charleston County Sheriff’s Office spokesman Eric Watson says that Eachus’ bond hearing is scheduled Friday afternoon at 2 p.m.The mouse is arguably the most widely used mammalian model in biomedical research. ![]() A video found on one of the devices allegedly shows two children striking each other with a belt, while another series of photos depicts two of the children as siblings engaged in sexually explicit activity.Īccording to the Al Cannon Detention Center website, Eachus was booked on the afternoon of Oct. Detailed descriptions of the dozens of photos and videos allegedly found on these devices include depictions of more than 40 children that appear to vary in age from six to 16 years old.ĭescriptions accompanying the photos include terms like “for the first time” and “romantic mouse,” according to arrest affidavits, which go on to explain that “Siberian Mouse” is used to describe a known series of photos that depict a child in a state of sexually explicit nudity and is often traded online as child pornography. ![]() The affidavit goes on to state that Eachus confessed to his employer that he had used computer equipment owned by the company and assigned exclusively to him to transfer files among his personally owned external storage devices while he was working at Boeing’s North Charleston facility.Īccording to the affidavit, Eachus “voluntarily surrendered the external storage devices to his employer,” which were then handed over to the Sheriff’s Office. 7, a detective with the Charleston County Sheriff’s Office was notified by Boeing that several digital files containing “depictions of minors engaged in sexual activity” were located on external storage devices belonging to employee Pitak Ot Eachus, according to an arrest affidavit. A 47-year-old North Charleston man faces 10 charges of third-degree sexual exploitation of a minor after allegedly using company equipment to transfer child pornography.
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